Macquarie MindScan has conducted the first 2HG magnetic resonance spectroscopy (MRS) investigation for a tumour case in the Southern Hemisphere. The presence of mutations of isocitrate dehydrogenase (IDH) has been reported within brain tumours (gliomas) and has significant implications for the patients prognosis. These mutations have been associated with the accumulation of 2-hydroxyglutarate (2HG) within the tumour. 2HG MRS is a ground breaking, non-invasive method which can measure the accumulation of 2HG within the tumour as an indicator of IDH mutations.

Together with our research partners, Macquarie MindScan is assessing the utility of this technique to provide improved diagnostic and prognostic accuracy. It is hoped that the development of a non-invasive, cost effective, more readily available method to investigate tumours will lead to prompt, individualised treatment schedules. Read more…

Magnetic resonance spectroscopy within a healthy brain

Magnetic resonance spectroscopy within a tumour identifying elevated 2HG

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